Along with oxidized LDL/HDL, testing for 8-oxoguanine provides important information about oxidative stress and its effects on DNA. The test is highly regarded as a measure of oxidative stress and well supported in the research literature.
This indicator focuses on the acceleration of aging due to potential DNA damage and is an effective way to evaluate the success of an intervention, whether it involves dietary change or antioxidant nutrients. Tracking the results of this test provides an indication of 1) whether there is a problem due to oxidative stress and 2) whether interventions are having an effect.
When antioxidant levels are sufficient, that prevents oxidative damage from free radicals. Healthy levels of antioxidants such as ascorbate mean efficient energy production in the cells.
Both 8-oxoguanine and oxidized LDL/HDL indicate higher levels of inflammation and oxidative stress throughout the body, factors that underlie almost any form of chronic illness.
The goal for 8-oxoguanine is a value of <5 ng/mg of creatinine indicating adequate antioxidant protection.
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