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Study Shows L-Carnitine is an Important Contributor to Cellular Energy Metabolism
The benefits of carnitine for extending life-span has recently been reconfirmed in a well done European study. Centenarians are characterized by weakness, decreasing mental health, impaired mobility, and poor endurance. L-Carnitine is an important contributor to cellular energy metabolism. This study suggests that supplementation with the amino acid L-carnitine improves cognitive function and reduces fatigue in seniors.

Method: RCT on 66 centenarians ( > 100 yrs) who were suffering from fatigue after even slight physical activity. They were randomized to either placebo or carnitine (l-carnitine, levocarnitine 2 gm/day orally) for 6 months and followed up for a further 6 months.

Results: Statistically significant improvements in the active treatment group in relation to mental and physical fatigue (both p <0.001) and walking distance (p < 0.001), and these were associated with an increase in lean mass (p<0.01).
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Source: Malaguarnera M. et al. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007 Dec;86(6):1738-1744.